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  • KCUMB Faculty Authors Reference Book on GAPDH Enzyme

    Seidler Norbert

    KANSAS CITY, Mo. (April 10, 2013) – To Norbert Seidler, Ph.D., professor and chair of biochemistry at Kansas City University of Medicine and Biosciences, it’s all about enzymes, those large biological molecules responsible for the thousands of chemical interconversions that sustain life. His new book, GAPDH: Biological Properties and Diversity, presents research and new findings on the multiple functions of one enzyme in particular, glyceraldehyde 3-phosphate dehydrogenase (GAPDH).

    GAPDH is a glycolytic enzyme that catalyzes or activates the sixth step of glycolysis, the process of breaking down glucose for energy and carbon molecules.  

    In his new book, Dr. Seidler provides a comprehensive reading on GAPDH. Citing his own findings and observations along with more than 900 supporting research articles, Dr. Seidler introduces the concept that GAPDH performs multiple functions besides acting as a catalyst in a cell’s glycolytic process.

    “The construction and arrangement of the physical components of the cell, as well as integration of the various signals that allow for an efficient network of communication in the cell, are functions that specialize to the type of tissue in the body and appear to go awry in disease,” according to Dr. Seidler.

    “The book initiates a whole new perspective on health and disease,” he said. “It introduces a perspective that suggests that our cells have a much greater dynamic and resilient nature than is currently implied by our textbook understanding of cell function.”

    As a volume of Springer Publishing Company’s series Advances in Experimental Medicine and Biology, Dr. Seidler’s 295-page book will serve as a resource for biomedical researchers and scientists developing antibiotics, anti-cancer agents, and anti-apoptotic agents.

    Dr. Seidler is a graduate of Princeton University with a bachelor of arts in psychology. He earned a doctorate in biochemistry at the University of Medicine and Dentistry of New Jersey-Graduate School of Biomedical Sciences.

    Posted: 04/10/2013

    Category: Faculty, Research