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    Regulating Fetal Hemoglobin and Erythropoisesis

    Flavia Costa, Ph.D., Research Instructor, College of Biosciences, KCUMB, presents Regulating Fetal Hemoglobin and Erythropoiesis as an Intervention for Sickle Cell Disease.

    Sickle Cell Disease (SCD) is a common genetic disorder that affects approximately 1 in 1,800 newborns in the U.S. including 1 in 400 African-American infants. High levels of fetal hemoglobin (HbF - g-globin gene) in adulthood is the most potent modifier of disease severity. Thus, research has focused on elucidating pathways to increase g-globin expression in adulthood, as therapy for SCD.
    While SCD treatment strategies are focusing in the modulation of the globin genes (g-globin gene expression), other therapies need to be implemented early in the infant’s life to manage the severity of SCD clinical symptoms. Therefore, this presentation will focus on two different biological pathways that might lead into the development of new SCD therapeutic strategies.
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    Date: 04/11/2014

    Time: 11:00 AM

    Location: KCUMB Campus

    Category: Alumni