Bio

  • Norbert Seidler, Ph. D.

    Professor, Chair
    • Department: Biochemistry, Basic Medical Sciences, Biochemistry
    • Phone: 816-654-7612
    • Campus Office: DCR-208
    Member of faculty since: 1991
    Curriculum Vitae

    Education

    • Ph.D. in Biochemistry, UMDNJ - Graduate School of Biomedical Sciences, 1988
    • B.A. in Psychology, Princeton University, 1981

    Teaching Interests/Courses

    • Role of GAPDH in neuronal apoptosis: This glycolytic enzyme exhibits multiple non-glycolytic functions that depend on protein modification
    • Principles of protein folding: The concepts associated with this theme include molecular chaperones, intrinsic disorder and protein denaturation
    • Neurodegenerative diseases: Many neurologic diseases in this category are considered disorders of protein conformational integrity
    • Diabetic Complications: Nearly all of the health complications associated with diabetes stems from protein glycation (non-enzymatic glycosylation)
    • Chronic Diseases of Aging: Molecular mechanisms that are associated with aging-related diseases include chemical modification of proteins

    Research Interests

    • Alzheimers Disease: Formation of polyacrolein-protein composites is associated with the disease mechanism
    • Anesthetic Preconditioning: Inhaled anesthetics promote a cellular response to dehydration-induced protein aggregation
    • Biological Properties and Diversity of GAPDH: The pervasive multi-functionality is pivotal to understanding the integration of cellular activity
    • Post-Operative Cognitive Dysfunction: Anesthetic-induced formation of melanoids derived from oxidized serotonin
    • Chemical Chaperones: Cells make (or obtain from the diet) small compounds that promote conformational integrity of proteins

    Professional Affiliations

    Last updated on: 10/30/2012 8:52:00 AM