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Topic: Population Health
KCUMB's University Lecture Series features lectures and presentations from a broad spectrum of national and international speakers on topics that are relevant to the diverse University community. The series is directed by Seft Hunter, Ph.D., director of sponsored programs, along with a committee made up of faculty, staff and students.
Presentations are from 9-10 a.m. on the KCUMB campus, and will be followed by a 30-minute question-and-answer session. Doors typically open at 8:30 a.m. Lectures are open to KCUMB students, faculty, staff and alumni.
For questions about this event, please contact Dana Buchanan, at email@example.com.
Presentation Title: Estimating the impact of community based HIV counseling and testing (HCT) on HIV incidence in South Africa and UgandaPresenter: Ruanne Barnabas, MBChB, DPhil, Assistant Professor, Department of Global Health, Division of Allergy and Infectious Diseases, University of Washington
Dr. Barnabas is an Infectious Disease Physician-Scientist at the University of Washington and affiliate at the Fred Hutchinson Cancer Research Center. She completed her medical training at the University of Cape Town, her doctorate in mathematical modeling at the University of Oxford and her Infectious Diseases training at the University of Washington. Her research focuses on HIV treatment and prevention, specifically on interventions that reduce HIV viral load and, consequently, disease progression and transmission. Her projects use both empiric data and mathematical models to better understand HIV clinical progression and transmission, and estimate the potential impact of HIV interventions at population level. The ultimate aim of her work is to estimate the effectiveness and cost-effectiveness of HIV treatment and prevention interventions to inform clinical trial design.Synopsis: Mathematical modeling studies of HIV testing with current treatment guidelines can estimate impact on population HIV incidence. We used a validated HIV transmission model HIV and viral suppression among HIV-positive persons to estimate the impact of community-wide home-based HIV counseling and testing (HBCT) and linkages on HIV incidence in KwaZulu-Natal, South Africa. Of 1,273 adults tested, 404 (32%) were HIV-positive; 158 (39%) were on ART and 127 (32%) were ART eligible (CD4≤350 cells/µL). By month 12, 111 participants initiated ART and viral load was suppressed among 69% of all HIV-positive persons. Modeling estimates 1) HBCT every 5 years with ART at CD4≤350/µL would decrease HIV incidence, over 5 and 10 years, by 31% and 33%, respectively, 2) ART initiation at new WHO guidelines (CD4≤500 cells/µL) would decrease incidence by 41% and 45%, respectively
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Presentation: Exploiting Necrosis for the Diagnosis and Therapy of Solid Tumors Speaker: Luis Diaz, M.D.
Dr. Diaz is the Assistant Professor of Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital. His area of research includes combining basic science research with clinical knowledge to produce novel diagnostic, predictive and therapeutic agents for cancer patients.His area of concentration in the laboratory has been in the preclinical development of the concept of COBALT (Combination Bacteriolytic Therapy) as well as in the development of a clinical protocol for testing this concept. His presentation will focus on the preclinical development of COBALT and the development of future therapeutic agents.
Presentation: Musculoskeletal Ultrasound as a Research and Diagnostic ToolSpeaker: Blake Boggess, D.O.
Dr. Boggess is a team physician for Duke University Athletics and assistant professor in orthopedic surgery and assistant professor in community and family medicine at the Duke University School of Medicine. He has directed and taught many musculoskeletal ultrasound courses nationally and internationally. He performs over 1,400 musculoskeletal ultrasound procedures each year and teaches students, residents, fellows and faculty ultrasound techniques.In addition to his role as team physician for Duke University’s athletes, he serves as team physician for North Carolina Central University and Panther Creek High School. He is a member of the American Medical Society for Sports Medicine, American Academy of Osteopathic Sports Medicine, and the American Academy of Family Physicians.Dr. Boggess’ research interest include issues related to Musculoskeletal Ultrasound, Non-operative Orthopedics, PRP- Platelet Rich Plasma Injections, Heat Illness, Concussion, Orthopedic Physical Examination and Electrolyte Imbalance in Exercise. His presentation will focus on how musculoskeletal ultrasound can be used as both a research as well as a diagnostic tool.
Presentation: Sugar Cubed: How Sugar and High Fructose Corn Syrup Affects Obesity and Metabolic Risk in ChildrenSpeaker: Michael I. Goran, Ph.D.
Dr. Goran holds appointments as professor in the departments of preventive medicine, physiology & biophysics and pediatrics in the Keck School of Medicine at the University of Southern California. He is the founding director of the USC Childhood Obesity Research Center and holds the Dr Robert C and Veronica Atkins Endowed Chair in Childhood Obesity and Diabetes. His research has focused on the causes of consequences of childhood obesity for over 20 years. Dr Goran is a native of Glasgow, Scotland, and received his Ph.D. under the direction of Keith Frayn, from the University of Manchester, UK (1986) prior to postdoctoral training in the US (1987 to 1991). He previously served on the faculty of Medicine at the University of Vermont (1991 to 1994), and the Department of Nutrition Sciences at UAB (1994 to 1999) prior to joining USC in 1999.Dr. Goran will be discussing the many ways in which dietary sugar and high fructose corn syrup affects obesity and obesity related metabolic conditions like type 2 diabetes and fatty liver disease in children. Also covered will be how factors at numerous levels influence these associations including genes, physiology/metabolism, behavior, economic factors and trade policy.
Presentation: Type 1 Diabetes Pathogenesis and Treatment Beyond the TextbookSpeaker: Dorothy J. Becker, M.B.B.Ch.
Dr. Becker’s presentation explores results of a 10 year study aimed at examining ways to prevent insulin dependent diabetes.
Dr. Becker is a professor of pediatrics, director, division of Endocrinology, Metabolism and Diabetes Mellitus in the department of pediatrics at the Children’s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine. Dr. Becker received her M.B.B.Ch. degree from the University of Witwaterstrand, Johannesburg, South Africa.
Dr. Becker has been involved with the clinical care of children with diabetes for 37 years , becoming the director of the Children's Hospital of Pittsburgh Diabetes Center , one of one of the largest pediatric programs ,in 1991. She is Principal Investigator of an almost 30-year continuously NIH-funded RO1 grant investigating the etiology and epidemiology of type 1 diabetes with the ultimate goal of the prevention of this disorder. In addition, she is the North American PI and Coordinator of a primary international prevention trial to assess the effect of weaning newborns to a hydrolyzed milk formula compared to standard cow milk formula. This trial, known as TRIGR, is currently in its 11th year with intervention completed and excellent compliance with follow-up. She is also the PI of the Pittsburgh Center of the International TrialNet Study which recruits both high-risk first-degree relatives of patients with type 1 diabetes as well as new onset type 1 diabetes patients for intervention studies aimed at preventing diabetes or preserving Cpeptide secretion. Dr. Becker has contributed to pediatric diabetes research in the areas of prevention of diabetes and its complications for three decades after completing a second fellowship in the Department of Endocrinology and Diabetes at the Children’s Hospital of Pittsburgh. She then received a CAP Award and was Associate Director of the Children’s Hospital of Pittsburgh GCRC from 1981-1994 until she became Division Chief. She was President of the North American Lawson Wilkins Pediatric Endocrine Society 2009-2010 and has received a number of other awards, including being named Best Doctor over the years, ADA diabetes in Youth Award and International Society for Pediatric and Adolescent Diabetes Prize for Achievement.
Presentation: Developing Pharmaceutical Therapies Against Threats Posed by Bioterrorism and Emerging DiseasesSpeaker: Dennis E. Hruby, Ph.D.
Dennis E. Hruby, Ph.D., has served as SIGA’s Chief Scientific Officer since June 2000, and was the Vice President of Research from April 1997 through June 2000. He received his Ph.D. in Microbiology from the University of Colorado Medical Center and holds an undergraduate degree in Microbiology from Oregon State University. He conducted virology research as an NIH postdoctoral fellow at the University of Wisconsin, Madison, from 1979 through 1982, and at the State University of New York, Stony Brook, from 1977 through 1979. He specializes in poxviruses, virology and anti ‐infective research. He has published more than 210 manuscripts/chapters, 400 abstracts and currently holds approximately 200 US and international patents for methods of use, compounds, and pharmaceutical compositions.
His presentation will focus on his work to develop an antiviral drug for smallpox within the broader context of creating a national stockpile for biodefense purposes. He will also discuss the additional challenges of emerging diseases and the need for developing medical countermeasures.
Presentation: Intersection of Lipid Metabolism and Inflammation: The Development and Progression of Atherosclerosis Speaker: David Ford, Ph.D.
Dr. David Ford is Professor and Director of the Center for Cardiovascular Research at St. Louis School of Medicine. His lab is interested in biochemical mechanisms responsible for the pathophysiological sequelae of cardiovascular diseases including ischemic heart disease and atherosclerosis. Dr. Fords areas of research focuses on enzymic and free radical targeting of membrane phospholipids, alterations in lipid metabolism, and alterations in signaling pathways as mechanisms involved in cardiovascular diseases.
His presentation will focus on how human atherosclerosis is mediated through a complex array of inflammatory mechanisms and lipid products. These mechanisms will be reviewed. He will also explore recent development in the targeting of host tissue plasmalogens by HOCl that leads to an array of chlorinated lipids which may potentially be mediators of atherosclerosis as well as biomarkers of cardiovascular disease. Finally a vignette that ties the accumulation of cholesterol and chlorinated lipids with the ability to remove cholesterol from the vascular wall will be introduced.
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