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KCU students will be calling alumni April 26-29
Free CME for KCU alumni
KCU's Science Friday Talks features lectures and presentations from a broad spectrum of national and international speakers on topics that are relevant to the diverse University community.
Presentations are from 12:30 to 1:30 p.m. in Classroom B of the Annex on KCU campus, unless otherwise noted. Lectures are open to KCU students, faculty, staff and alumni.
For questions about this event, please contact Dana Buchanan at email@example.com.
Presenter: William D. Picking, PhD, Distinguished Professor/Director, Pharmaceutical Chemistry, University of Kansas, Lawrence, Kan.Date: April 10Time: 12:30 - 1:30 p.m.Location: Classroom B Topic: Type III secretion (T3S) systems are important nanomachines used by numerous Gram-negative bacteria to deliver effector proteins to targeted eukaryotic cells to alter their normal functions. The T3S apparatus (T3SA) of Shigella flexneri architecturally resembles a syringe and needle with control of secretion occurring via proteins found at the tip of the surface-exposed needle and proteins located at the base of the T3SA within the bacterial cytoplasm. My group has been examining the structure-function relationships of the invasion plasmid antigens (Ipa proteins) that form the T3SA needle tip complex (IpaD, IpaB and IpaC) and their temporal recruitment to the T3SA needle tip. These multi-purpose proteins are essential virulence components for S. flexneri and they are potential targets for blocking bacterial invasion of human intestinal cells. More recently, we are making inroads into understanding the structure and architecture of the T3SA ctypoplasmic complex that is implicated in powering T3S and sorting/presenting the proteins that are the substrates of T3S for Shigella. In the end, we hope to develop a complete understanding of how the onset of T3S is controlled in this important pathogen with potential applications for targeting this and T3S systems from other pathogens for new anti-infective strategies. | Download flyer
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